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Coffee Drinkers Take Note: Caffeine, Vitamin D Receptor Expression, Phenols and Digestive Enzymes...

If you have questionable vitamin D status, this post may be of interest.

It turns out, caffeine inhibits the Vitamin D receptor [1]. Yep.

So, if you are trying to up your vitamin D status, i suggest considering liposomal Vitamin D (QuickSilver Scientific K2/D3) first thing in the AM, and then before bed. Caffeine stays in your system around 6-12 hours depending on your ability to metabolize it:).

For another post, but important co factors for Vitamin D assimilation and synthesis include:

  1. Zinc (liquid Zinc Sulfate - Mary Ruths is a favorite),

  2. Magnesium (Ultra Mag By Pure Encaps, Mag SRT Mag Malate By Jigsaw Health, MagMind By Jarrow - Mag Threonate all favorites, and all second to epsom salt baths).

  3. K2 (make sure you get enough, 400mcg / day)

  4. B6

Other factors that effect Vitamin D - include compromised ability to absorb fat suluable nutrents, bile and or pancreatic enzyme shortages. You may be interested to know that phenols inhibit pancreatic digestive enzymes (coffee gets a double whammy here for inhibiting the digestion of fat soluable vitamins like D in the gut) [2]. Coffee is super high in phenols, and so are teas:).

Now my suggested Vit D form, begins to take more shape:).


[1] Caffeine decreases vitamin D receptor protein expression and 1,25(OH)2D3 stimulated alkaline phosphatase activity in human osteoblast cells.

Prema B Rapuri. Journal Steroid Biochemistry Mol Biol. . 2007 Mar;103(3-5):368-71.

doi: 10.1016/j.jsbmb.2006.12.037. Epub 2007 Jan 12. PMID: 17223552.

[2] Understanding phenolic acids inhibition of α-amylase and α-glucosidase and influence of reaction conditions. Andrea Aleixandre . Food Chemistry

Volume 372, 15 March 2022, 131231.

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