top of page

Anti Fungals (Griseofulvin, and other anti fungals sprayed on crops) - One Reason Why They Bring Some People To Their Knees.....

This article is not medical or healthcare advice. Before you start any health related regimen seek the advice of your Primary Care Physician or an M.D.


There are many stories of people who have benefited from anti fungal therapy, in the case of fungal associated illness. And there are also horror stories where people have become train wrecks after trying anti fungals. This article explores some of the potential reasons why one anti fungal - griseofulvin - can cause significant issues for some.


It has to do with the effect it has on two genes in the heme pathway. For a primer on the heme pathway, see my earlier post on some of the basic steps in the heme pathway, and more details:



To cut to the chase, said simply this anti fungal - griseofulvin - affects two genes:

  1. It induces ALAD, which is in the early part of the heme pathway, thus attempting to drive more heme production through the rest of the steps in the heme creation process.[1] However, if there are any bottlenecks in these later steps, it can lead to the buildup of toxic porphyrns, which cause significant side effects explored in the article noted above.

  2. It inhibits (blocks) the last step in the heme pathway, the gene FECH [2]. So here comes the block that is the issue, and a build up of toxic porphyrns, and low levels of heme for hemoglobin, and all sorts of other pathways (CYP450, GPX, NAD, etc).


The FECH gene also requires B6, Zn, and Cu to function properly, so even partial deficiencies in these nutrients, especially across several of these co factors simultaneously for FECH can become more problematic with Griefesolin use.


So this particular anti fungal - griseofulvin - can create a double whammy on the heme pathway - inducing too much heme activity up front in the pathway, and blocking it downstream. Even worse, the myco toxin Zearalanone - raises IL-10, which can inhibit another step in the heme pathway.


As I come across other such reports for anti fungals i will post them within this blog article. However, there are studies that reveal various fungi do aim to acquire extrenal heme - in particular Candida Albicans. [2] How interesting!


Sampangine (anti malarial, anti fungal) - inhibits heme synthesis as well.

"In this study, we show that inhibition of heme biosynthesis is the primary mechanism of action by sampangine and that increases in the levels of reactive oxygen species are secondary to heme deficiency. We directly demonstrate that sampangine inhibits heme synthesis in the yeast Saccharomyces cerevisiae. It also causes accumulation of uroporphyrinogen and its decarboxylated derivatives, intermediate products of the heme biosynthesis pathway. Our results also suggest that sampangine likely works through an unusual mechanism—by hyperactivating uroporhyrinogen III synthase—to inhibit heme biosynthesis."[3] It is quite effective as an anti fungal on plants, so muc so, it was patented by the University of Mississippi back in 1990. Ugh. "According to the new patent--US No. 6,844,353--sampangine-based compounds can control such fungi as Botrytis cinerea, which causes gray mold on tomatoes; Colletotrichum fragariae, which produces anthracnose crown rot and wilt in strawberry plants; C. gloeosporioides, which sickens numerous plants, including grapes, strawberry, citrus and papaya; and Fusarium oxysporum, which induces vascular wilt in crops such as potato, sugarcane and many ornamentals."[4]


Should you wish to explore this topic in more detail, review your genetics, or look into testing options, feel free to schedule an appointment on line, or reach out to me to request one while providing good days and times that work for you.


References:

  1. Protoporphyrin IX: the Good, the Bad, and the Ugly. Madhav Sachar, Karl E. Anderson, and Xiaochao Ma. The Journal of Pharmacology and Experimental Therapeutics. American Society for Pharmacology and Experimental Therapeutics. J Pharmacol Exp Ther. 2016 Feb; 356(2): 267–275. Published online 2016 Feb. doi: 10.1124/jpet.115.228130

  2. ReviewPathways of heme utilization in fungi. Daniel Kornitzer, Udita Roy. Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. Volume 1867, Issue 11, November 2020, 118817. https://doi.org/10.1016/j.bbamcr.2020.118817

  3. Sampangine Inhibits Heme Biosynthesis in both Yeast and Human . Authors: Zhiwei Huang, Kaifu Chen, et al. ASM Journals. Eukaryotic Cell. Vol. 10, No. 11.

  4. Medicinal Compound Gets New Life as Fungicide. ByLuis Pons. February 23, 2005USDA Agricultural Research Service. U.S. Department of Agriculture.


28 views0 comments

Recent Posts

See All
bottom of page